GROUP SEQUENTIAL DESIGN FOR TIME-TO-EVENT OUTCOME WITH NON-PROPORTIONAL HAZARDS USING THE CONCEPT OF RELATIVE TIME UTILIZING TWO DIFFERENT WEIBULL DISTRIBUTIONS

A group sequential design allows investigators to sequentially monitor efficacy and safety as part of interim testing CELLULITE CONTROL in phase III trials.Literature is well developed in the case of continuous and binary outcomes, however, in case of trials with a time-to-event outcome, popular methods of sample size calculation often assume propo

Active noise control (ANC) aims to reduce a noise source at a listening point by destructive interference with a reverse phase noise emitted by one or more control devices.ANC systems cover a wide range of applications, such as industrial plants, vehicle cabins, headphones.Usually, in these applications the control devices are loudspeakers, and the

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